Hey , I'm sorry to hear that your supplements are no longer working! Hopefully someone here can respond with some suggestions. Have you told your doctor that the regime you're on is no longer helping? That might be the best place to start! I also found a couple articles that might be helpful in the meantime.
This author gives a list of supplements they use for their IBS symptoms: https://irritablebowelsyndrome.net/living/daily-supplements
And this one talks about fiber and laxatives for constipation: https://irritablebowelsyndrome.net/treatment/fiber-laxatives
I hope you find some answers soon! Please keep in touch. - Kat (Team Member)