I'm so sorry that you're dealing with all this. I have never tried anti-depressants before, but we have this article that mentions them as a treatment option: "Both tricyclic and SSRI (selective serotonin reuptake inhibitors) antidepressants have historically demonstrated benefits in the treatment of IBS." (https://irritablebowelsyndrome.net/treatment). I hope that other community members will share their experiences with you! All the best, Karina (team member)