Hi All I've been suffering with IBS-D for 4 years now and have been on a 50mg dose of amitriptyline which has actually worked really well for managing symptoms but have come with some severe side effects. For the last year or so I've felt very disassociated and empty so I'm taking action to change my treatment plan. Can anyone suggest any medication they are currently on for IBS-D that isn't an antidepressant as unfortunately the doctor's have simply told me "Do some research and tell us what medication you would like to try".