Skip to Accessibility Tools Skip to Content Skip to Footer

Trulance (plecanatide)

Trulance® (plecanatide) is a prescription medication approved to treat adults with irritable bowel syndrome with predominant constipation (IBS-C). It is also used to treat adults with chronic idiopathic constipation.1

What are the ingredients in Trulance?

The active ingredient in Trulance is plecanatide.1

How does Trulance work?

Trulance is an analog of uroguanylin, a substance that is naturally found in the body and plays a role in the amount of fluid in the intestines. Too little fluid in the digestive system can lead to hard stools and constipation, while too much fluid can lead to diarrhea. Trulance acts as a guanylate cyclase-C (GC-C) agonist which ultimately increases the amount of fluid in the intestines, accelerates the intestinal transit (the movement of food through the digestive tract), and reduces constipation.1,2

What are the possible side effects of Trulance?

In clinical trials, the most common side effect experienced by people taking Trulance was diarrhea. Diarrhea can sometimes be severe, and if it occurs as a result of treatment with Trulance, it most likely occurs within the first 4 weeks of treatment. People who experience diarrhea while they are taking Trulance should stop taking Trulance and contact their doctor.1,2 This is not an exhaustive list of side effects so patients should consult their doctor if they experience anything unusual while taking Trulance.

Things to know about Trulance

Trulance should not be used in children up to 6 years of age and it is not known if it is safe for children under the age of 18, so its use should be avoided as it may harm them.

People who have been told they have a bowel obstruction should not take Trulance.

Before beginning treatment with Trulance, patients should talk to their doctor about all medical conditions and all medications (prescription and over-the-counter), vitamins, and supplements they are taking. Some medications or supplements can cause negative reactions when mixed.

It is not known if Trulance is safe to take during pregnancy or breastfeeding. Women who are pregnant or breastfeeding, or who plan to become pregnant or to breastfeed, should discuss with their doctor appropriate treatment options.1,2

Dosing information

Trulance comes in a 3 mg tablet which should be taken by mouth once daily. Trulance may be taken with or without food, and the tablets should be swallowed whole (not chewed or crushed).1

For more on Trulance, read the full prescribing information.

Emily Downward | Last reviewed: July 2019
  1. Trulance prescribing information. Available at Accessed 1/31/18.
  2. Trulance brand website. Synergy Pharmaceuticals. Available at Accessed 1/31/18.