Reviewed by: HU Medical Review Board | Last reviewed: March 2023

Linzess is a prescription medicine used to treat adults with irritable bowel syndrome with constipation (IBS-C).1

Linzess is not a laxative, although both laxatives and drugs like Linzess work to relieve constipation. Linzess is a guanylate cyclase-C (GC-C) agonist. Guanylate cyclase is an enzyme found in the lining of the intestines, and Linzess binds to this enzyme to stimulate a response.2

As a GC-C agonist, Linzess is thought to bind to the receptor sites in the intestines, which creates two effects: reducing the amount of pain felt by helping calm the pain-sensing nerves, and accelerating bowel movements by increasing the fluid in the intestinal space.1,2

In clinical trials, Linzess showed significant reduction in abdominal pain and in easing constipation among people with IBS-C. People taking Linzess were more likely to experience more frequent and complete bowel movements compared to people on a placebo.1

Possible side effects with Linzess

The most common side effect with Linzess is diarrhea, which can sometimes be severe. Diarrhea often begins within the first two weeks of taking Linzess, and people who experience severe diarrhea should stop taking Linzess and call their doctor.1

Other common side effects experienced with Linzess treatment are:

  • Gas
  • Abdominal pain
  • Swelling
  • Feeling of fullness or pressure in the abdomen

Rarely, severe abdominal pain or bloody or black stools may be experienced with Linzess. People are advised to go to the emergency room or call their doctor if they experience these adverse effects.1

These are not all the possible side effects of Linzess. Talk to your doctor about what to expect or if you experience any changes that concern you during treatment with Linzess.

Taking Linzess

Linzess was studied and found to be effective when taken daily, generally at the same time of day, 30 minutes prior to the first meal. When taken daily, Linzess may help manage the symptoms of IBS-C.1

It may be helpful to put it in a place where it is visible as a reminder to take it daily, but people are instructed to keep Linzess out of the reach of children. In addition, Linzess should be kept in its original bottle and stored at room temperature.1

Who should not take Linzess

Linzess is approved for use only in adults. It should not be used in children under age 2, as there is a serious risk for dehydration. Linzess is also not to be used in people who have a bowel blockage. It is unknown if Linzess is safe to take while pregnant or breastfeeding. Women who are pregnant or breastfeeding should talk to their doctor before using Linzess.1

Additional treatment options for IBS

No one remedy works for all people, and people with IBS often find they must try a variety of treatment options to manage their symptoms. Most people find a combination of approaches work best. In addition to medicine, other treatment strategies include diet changes, probiotics, stress management, exercise and alternative therapies.

Before beginning treatment for IBS, tell your doctor about all your health conditions and any other drugs, vitamins, or supplements you take. This includes over-the-counter drugs.

By providing your email address, you are agreeing to our privacy policy.