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I'm sorry to hear you are having bad luck with the suppositories. I haven't had this particular problem, but have struggled with rather severe bloating issues. My doctor was able to prescribe medication that helped a good deal. I would have a conversation with the doctor, if you haven't already. Perhaps there is an alternative approach. Hopefully, someone might chime in who has had a similar experience. Please keep us updated. I hope you are well today. -Todd, IrritableBowelSyndrome.net Team