caret icon Back to all discussions

A 5-htp supplement caused IBS for me!

Hey everyone, I took a dose of 100mg of 5-hydroxytryptophan (5-htp, serotonin precursor) over a month ago and felt a pressure in my guts after half an hour or so. Also moderate pain in my belly for a few hours.

The next day I went to the bathroom like 5-7 times and had a feeling of incomplete bowel movements. This happens now every day. My stools also get increasingly wet and loose over the day. In the evenings I am bloated af with lots of gut noises and especially the colon (especially left lower abdomen) has a pressure like and sore feeling throughout the day which builds up during the day.

These are my symptoms up until today since I took that supplement. My digestion was flawless before!

Tried fodmap already but it gives only a slight relief.

I know that I am sensitive to serotonergic drugs and I should have never tried the supplement but I am shocked about how long this confuses my guts.

I know about the mechanism of serotonin (motility wise) in the intestines and how 5-htp addresses the enterochromaffin cells.

But I am still wondering if anyone experienced something similar? It seems one pill has completely disrupted that fine tuned system.

  1. Hey , I'm so sorry to hear that you've been suffering for the past month. I don't have any experience with this, but I hope someone here can chime in with some insight. That's really frustrating that it happened so suddenly. I'm going to link an article about tryptophan that you may find helpful: https://irritablebowelsyndrome.net/living/tryptophan. I also would suggest speaking with your doctor to make sure it's safe for you to continue taking the supplement. Was it a doctor who prescribed it or did you get it over the counter? - Kat (Team Member)

    Please read our rules before posting.