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Ibsrela (tenapanor)

Tenapanor (Ibsrela®) is a new treatment for 11 million adults with IBS-C. It is what is known as a sodium/hydrogen exchanger 3 (NHE3) inhibitor.1-2

What are the ingredients for tenapanor?

Tenapanor hydrochloride is the active ingredient. Inactive ingredients include colloidal silicon dioxide, hypromellose, low-substituted hydroxypropyl cellulose, microcrystalline cellulose, propyl gallate, stearic acid, tartaric acid powder, titanium dioxide, and triacetin.1

How does tenapanor work?

Tenapanor works by blocking the NHE3 transporter in the gastrointestinal tract, which increases sodium in the small intestine and colon. This increases fluid in the gut, which loosens and softens the stool and speeds transit time in the intestines. This helps relieve constipation for people with IBS. Tenapanor also reduces abdominal pain by decreasing gut sensitivity.1

Tenapanor works mainly in the GI tract, reducing the amount of drug absorbed into the bloodstream.2

Dosing information for tenapanor

Tenapanor (Ibsrela) is only approved for adults ages 18 years and older. The recommended dose for adults is a 50 mg tablet taken twice daily, immediately before breakfast or the first meal of the day, and immediately before dinner.1

If you miss a dose, take the next dose at your regular time. Do not take two doses at the same time.

Possible side effects of tenapanor

In two clinical trials with 1,203 adults, the most common side effects were diarrhea (16 percent), abdominal distension, gas (flatulence), and dizziness. However, these symptoms were similar to those treated with a placebo.11

Who should not take tenapanor

Tenapanor should not be taken by people with a known or suspected gastrointestinal obstruction. It also should not be used in children 18 and younger. Juvenile rats given tenapanor died of dehydration, so the drug is particularly not recommended for children 6 or younger.1

It is not known if Tenapanor is safe for pregnant or breastfeeding women and their babies.2

Additional treatment options for IBS-C

People with IBS often find that they must try a wide variety of treatment options to find the right combination to manage their unique symptoms. In addition to drugs, some of the more common approaches include dietary changes, stress management, probiotics, exercise, aromatherapy, acupuncture, and biofeedback.

For more information on tenapanor, read the full prescribing information.

  1. Full Prescribing Information. Ardelyx, Inc. Available at: Published September 2019. Accessed October 1, 2019.
  2. Ardelyx. What we do. Available at: Accessed October 1, 2019.