Lotronex (alosetron HCl)

Reviewed by: HU Medical Review Board | Last reviewed: March 2022 | Last updated: March 2022

Lotronex (alosetron HCl) is a prescription medication for women with severe chronic irritable bowel syndrome with diarrhea (IBS-D). Lotronex may help female patients who have severe diarrhea from IBS, who have been experiencing IBS-D for six months or longer, and who have not gotten relief from any other medications they have tried.1

Lotronex is a serotonin 5-HT3 receptor antagonist. Serotonin is a chemical in the body that is involved in the messages of pain perception, the sleep-wake cycle, and mood. Ninety-five percent of all the serotonin in the human body is found in the gut. As an antagonist, Lotronex blocks the receptor sites where serotonin usually binds. It is believed that too much serotonin in the gut may cause bowel movements to occur too quickly, leading to bowel urgency and diarrhea, as well as more sensitivity to pain and discomfort in the abdomen. Blocking the serotonin from binding to the receptors may help reduce some of the symptoms of severe IBS with diarrhea.1

Taking Lotronex

Lotronex works by reducing the effects of having too much serotonin in the intestines. It is recommended that patients who are prescribed Lotronex take it every day – not just when symptoms flare.1

Who shouldn’t take Lotronex

There has not been enough data to support if Lotronex is safe and effective for men or for children under the age of 18. In addition, Lotronex should not be used by patients with IBS with constipation (IBS-C) or by patients who are currently experiencing constipation. Patients who have experienced bowel blockages, blood clots, Crohn’s disease, ulcerative colitis, diverticulitis, severe liver disease, ischemic colitis or who are taking a medication called Luvox® (fluvoxamine) should not take Lotronex.1

There are no studies that demonstrate Lotronex is safe during pregnancy or for women who are breastfeeding, as it may cause harm to the child. Women who are pregnant or breastfeeding should discuss treatment options with their doctor.1

Possible side effects when taking Lotronex

The most common side effects experienced by patients taking Lotronex are constipation, stomach pain and nausea. If a patient experiences constipation while taking Lotronex, they should immediately stop taking it and call their doctor. Rarely, severe complications have been experienced by patients on Lotronex, including severe constipation and ischemic colitis – a condition where blood flow to the intestines is reduced or blocked, which may cause pain and damage to the colon. These conditions can lead to hospitalization, blood transfusions, surgery and even death.2,3 These are not all the possible side effects of Lotronex. Talk to your doctor about what to expect or if you experience any changes that concern you during treatment with Lotronex.

Additional treatment options for IBS

The imbalance of serotonin, which is believed to cause some IBS symptoms, also plays a role in mood and may be the reason why some antidepressants are effective medications for IBS patients.4

The management of IBS symptoms is usually accomplished by a combination of approaches, and determining the best combination for a patient may require some trial and error. There are several medications patients can try, as well as other treatment strategies such as adding exercise, making dietary changes, adding fiber, or trying complementary or alternative medicine.

By providing your email address, you are agreeing to our privacy policy.

More on this topic