I have had constipation all my life. It is worse in the summer due to heat and humidity. I have tried my different meds for this. I just tried Linzess. That was poison for me. I also suffer from Anxiety and Depression. When my IBS C is bad it triggers my anxiety. I have tried many different medications for depression. When I am suffering from IBS C I find I cannot focus on one thing at a time. I know I have some type of Attention deficit disorder. I have never been treated for it. I am going to discuss with my Phyc.