40 years of varying stages of IBS have taken their toll on my mental health, or is it the other way round ? As far back as I can remember ( its a long way back ) I have produced too much adrenalin, or is it seratonin ? Today I have a prescription for DESFAX which is a secondary seratonin uptake inhibitor which was prescribed as an alternative to CELAPRAM ( hydrobromide) I have been taking for 12 years but was affecting my libido! Overall I dont feel that Desfax works as well as my IBS is more intense with involuntary colon spasms both when I am on edge & during rest, sleep etc! Anyone else have this dilemma & found relief with either drugs or alternatives ?